Description
“These Statements Have Not Been Evaluated By The Food And Drug Administration.
This Product Is Not Intended To Diagnose, Treat, Cure Or Prevent Any Disease.”
For Research Use ONLY
AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is a potent, cell-permeable AMPK activator that simulates exercise and metabolic effects by increasing glucose uptake and fatty acid oxidation. It is a nucleoside analog that converts to ZMP inside cells to stimulate AMP-activated protein kinase.
Key Details About AICAR:
- Mechanism: AICAR is taken up by muscle cells and phosphorylated into ZMP, which acts as an AMP analog to stimulate AMPK activity.
- Metabolic Effects: It reduces fatty acid/sterol synthesis and increases GLUT4 translocation, which mimics the effects of exercise.
- Applications: Used in research for treating diabetes, ischemia/reperfusion heart injury, and chronic lymphocytic leukemia.
- Physical Properties: It is a white solid, soluble in water and DMSO
Benefits and Research Findings:
- Metabolic Control: AICAR improves glycemic control and reduces obesity in animal models.
- Performance: It can increase endurance in mice.
- Muscle Health: It has been shown to improve muscle function in Duchenne muscular dystrophy models.
- Anti-inflammatory: It reduces inflammation and acts as an antioxidant by activating Nrf2.
Note: AICAR is a prohibited substance and should not be used without proper, authorized research contexts.
