Description
“These Statements Have Not Been Evaluated By The Food And Drug Administration.
This Product Is Not Intended To Diagnose, Treat, Cure Or Prevent Any Disease.”
For Research Use Only, not for human or animal use
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid mitochondrial-derived peptide encoded in the 12S rRNA region of mitochondrial DNA (mtDNA). It functions as a hormone-like signaling molecule that translocates to the nucleus under metabolic stress to regulate gene expression, promoting metabolic homeostasis, insulin sensitivity, and anti-aging effects.
Key Scientific Aspects:
- Mechanism of Action: Activated by exercise and stress, MOTS-c moves to the nucleus, regulating genes with antioxidant response elements (ARE). It activates the AMPK pathway and improves mitochondrial metabolism, particularly in skeletal muscle, while enhancing fatty acid oxidation.
- Metabolic Regulation: It acts as an “exercise-mimetic” reducing diet-induced obesity, improving glucose uptake, and increasing NAD+ levels. It also suppresses the expression of myostatin, potentially reversing muscle atrophy.
- Clinical Significance: Levels decline with age, and its therapeutic potential is being investigated for obesity, diabetes, osteoporosis, and Alzheimer’s disease.
- Origin: It is one of the few mitochondrial-encoded peptides, alongside humanin and SHLPs, that communicate with the nucleus to regulate cellular adaptation
