Description
Tirzepatide lyophilized powder for research use only. Bacteriostatic water not included; please order if needed.
Key Scientific Aspects of Tirzepatide:
- Mechanism of Action: Tirzepatide functions as a dual agonist, mimicking the effects of the natural hormones GIP and GLP-1. It provides a synergistic enhancement of the incretin effect, with GIP receptor activation aiding in weight loss and GLP-1 primarily influencing glucose control.
- Molecular Structure: It is a 39-amino acid linear peptide, engineered from the native GIP sequence, with a C20 fatty diacid moiety attached. This lipidation allows for high albumin binding (99%) and a long half-life of approximately 5 days.
- Pharmacokinetics: It has a bioavailability of roughly 80% with peak serum levels reached in 8 to 72 hours.
- Metabolic Effects: It improves cell function, insulin sensitivity, and reduces hepatic glucose output. It is shown to significantly decrease body weight by reducing appetite and energy intake.
